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Introduction Levothyroxine monotherapy (Synthroid® or multiple generic levothyroxine [GL] formulations) is standard treatment for hypothyroidism. 326)] For what it's worth, when I started treatment for hypo the generic (levothyroxine) made me feel sick: headache, diarrhea, warm/burning skin (mostly across my face), and mild nausea. 6% of patients who took the generic levothyroxine and 20. The theoretical insensitivity of pharmacokinetics was confirmed when the reference drug, Synthroid, was compared to a generic candidate (). My primary care MD sent me to n Endo who switch me to the BRAND (synthroid) and all of hose side effects stopped I've read that pretty much generic is plus/minus 7mcg while Synthroid would likely be plus/minus 5mcg (random numbers). Even in going between mail order CVS and Walgreens in store pick up. I just wanted to post my experience over the last couple of weeks with generic and brand (synthroid) medicines. 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